Presentation

Our research unit

Biology and pharmacology of blood platelets: Haemostasis, thrombosis, transfusion

Blood platelets play a major physiological role in stopping bleeding (hemostasis) and, in pathology, in the occurrence and extension of arterial thromboses (myocardial infarction, stroke and peripheral arterial diseases). Abnormal platelet production and function is responsible for serious bleeding disorders. In addition to their involvement in hemostasis and thrombosis, platelets have multiple roles and participate in complex processes such as vascular inflammation, tissue repair, angiogenesis, atherosclerosis, innate and adaptive immunity, embryonic and metastatic dissemination.

For 30 years now, our research unit has been studying platelets in all aspects of their biology, genetics, pharmacology, clinical practice and transfusion. Our approaches are both fundamental and applied to biomedical issues.

The group is structured around two interdependent teams that are interested, respectively, in the mechanisms and defects of platelet production as well as the role of platelets in hemostasis and thrombosis and in transfusion. It relies on multidisciplinary expertise in molecular and cellular biology, electron and confocal microscopy, mass spectrometry, and animal models, and on a translational and clinical approach.

The main contributions of the unit include:

  • The identification and characterization of key platelet receptors, some of which are targets for antithrombotic drugs. In particular, purinergic P2 receptors, ADP (P2Y1 and P2Y12) and ATP (P2X1) receptors, each of which have a role in platelet activation. The P2Y12 receptor is the target of the drugs clopidogrel, prasugrel (anti-aggregating thienopyridines) and ticagrelor and cangrelor. It is deficient in patients who have a haemorrhagic diathesis that can be severe.
  • The molecular characterization of a large number of patients with Bernard-Soulier’s disease and the detailed study of the role of the GPIb-V-IX complex in platelet physiology.
  • The development of mouse models of platelet diseases and a wide range of animal models of thrombosis exhaustively characterized.
  • In the field of blood transfusion, the implementation and characterization of pathogen inactivation processes in labile blood products, plasma, platelet concentrates and, under investigation, red blood cell concentrates.

Today, UMRS 1255 continues work on these different themes. In addition, more recent projects are looking at the final stages of platelet production and how to improve their in vitro production. Finally, the study of the role of platelets in the mechanisms of TRALI (transfusion related acute lung injury), metastatic dissemination and inflammatory diseases completes the range of projects of the group.

Executive Committee

Christian Gachet, François Lanza, Pierre Mangin, Henri de la Salle

TEAM 1


Biology and pharmacology of platelets

Team manager : Dr Christian Gachet

See the team

TEAM 2


Biology of thrombopoiesis

Team manager : François Lanza

See the team

Microscopy

Manager : Anita Eckly-Michel

Jean-Yves Rinckel
Fabienne Proamer
David Hoffman

More information

Animal facility

Manager : Monique Freund

Catherine Ziessel
Senay Yildirim
Ketty Knez-Hippert
Alain Gillig
Flavien Goubert

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Administration

Administrative coordinator :
Amandine Baron

Secretariat :
Valérie Petri
(+ 33 3 88 21 25 25)

Team 1


Biology and pharmacology of platelets

Team manager : Dr Christian Gachet

Responsables de projets :

  • Pierre Mangin
  • Béatrice Hechler
  • Arnaud Dupuis
  • Julie Boisramé
  • Blandine Maître

Ingénieurs :

  • Catherine Ravanat
  • Nicolas Receveur

Techniciens :

  • Stéphanie Benoît
  • Catherine Bourdon
  • Patricia Laeuffer
  • Véronique Heim

Post-doctorants :

  • Marion Lavergne
  • Margot Carocci
  • Qiong Xiang

Doctorants :

  • Yannick Rabouel
  • Marie-Belle El Mdawar
  • Ahmed Muhammad-Usman
Voir l'équipe

Team 2


Biology of thrombopoiesis

Team manager : François Lanza

Responsables de projets :

  • Henri de la Salle
  • Catherine Leon
  • Nathalie Brouard
  • Catherine Strassel

Ingénieurs :

  • Catherine Angenieux

Techniciens :

  • Sylvie Moog
  • Josiane Weber
  • Léa Mallo
  • Sébastien Egard
  • Gabrielle Haas
  • Floryna Lefebvre

Post-doctorants :

  • Alicia Bornert
  • Thao Nguyen Hoang Trinh

Doctorants :

  • Camille Jost
  • Julie Boscher
  • Valentin Do Sacramento
Voir l'équipe