DR2 INSERM – Deputy Scientific Director EFS Alsace

Pierre Mangin obtained his Ph.D. in Molecular and Cellular Biology from the University of Strasbourg, France, in 2003. His thesis focused on the role of the platelet GPIb-V-IX complex, a receptor for von Willebrand factor. From 2003 to 2006, he completed a postdoctoral fellowship in the laboratory of Pr. Shaun Jackson (Australian Center for Blood Diseases, Monash University) in Melbourne, Australia. Currently DR2 INSERM within the U949 team in Strasbourg, France, he was promoted in 2014, Deputy Scientific Director of EFS Alsace.

His research projects focus on studying the role of blood platelets in hemostasis and arterial thrombosis. He is particularly interested in the initial stages of adherence of platelets to parietal proteins such as von Willebrand factor, collagen, fibronectin or laminin. His work also focuses on the importance of platelet adhesion receptors, including the GPIb-V-IX complex, GPVI, or alpha6 beta 1 integrins, as an anti-thrombotic target. More recently, his team has investigated the non-hemostatic functions of platelet adhesion receptors, such as maintaining vascular integrity during inflammatory processes or disseminating metastases.

Projects :

  • Study of the Role of Parietal Fibronectin in Platelet Adhesion and Activation
  • Role of GPVI in the interaction of platelets with fibrin
  • Study of the role of platelets in the maintenance of vascular integrity during inflammatory phenomena.
  • Study of the role of complex fluxes in platelet adhesion:
    (i) Study of pulsatile flux on platelet aggregation;
    (ii) Study of the role of fibrinogen and other low reactivity adhesive proteins;
    (iii) Study of the role of human atherosclerotic plaque material in pathological flow
  • Study of the role of platelets in the process of metastasis formation:
    (i) Development of in vivo models of metastasis;
    (ii) Development of models to study the interaction of platelet cancer cells;
    (iii) Study of the role of platelet alpha6beta1 integrin in metastatic dissemination;
    (iv) Study of the role of platelet count on the experimental formation of metastases
  • Study of stent thrombosis mechanisms

Publications

Nothing found.