IR EFS

Nathalie Brouard obtained her PhD in developmental physiology and functional differentiation at Paris VII-Denis Diderot University, France in 1998. From 1999 to 2006, she continued her research activities with a postdoctoral internship under the direction of Dr PJ Simmons, in which she investigated the characterization of human and murine stromal progenitors at the “Experimental Haematology Hanson Center for Cancer Research”, IMVS, Adelaide, Australia from 1999 to 2000, and then at the “Stem Cell Laboratory” at Peter MacCallum Cancer Institute, in Melbourne, Australia from 2000 to 2006. Named “Instructor” (Faculty Member of the University of Texas) from 2006 to 2012 at the “Center for Stem Cell Research,” Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center in Houston, under the direction of Dr. PJ Simmons and Dr. B Davis, his research have focused on the study of the hematopoietic niche during development. After a fixed-term contract from December 2012 to July 2014, she was appointed EFS researcher in the INSERM UMR S949 team under the direction of Dr. Christian Gachet at EFS-Alsace. She is interested in the role of the microenvironment during megakaryopoiesis. His areas of expertise include mesenchymal stem cells, hematopoietic stem cells, flow cytometry and cell sorting, animal models, microarray and bioinformatics.

Research Themes :

The production of megakaryocytes from hematopoietic stem cells is a complex process that involves a succession of steps, which lead to the hematopoietic progenitor commitment to the megakaryocytic differentiation pathway and then the megakaryocytic precursor maturation to lead to megakaryocyte formation. able to produce platelets, essential elements of the maintenance of hemostasis.

Each of these steps are regulated by a particular microenvironment whose cellular nature is little known. This project aims to identify the cellular elements of the microenvironment of megakaryopoiesis during the development of the hematopoietic system. We have identified several microenvironment cell populations in mouse fetal liver, one of which promotes the expansion of megakaryocytes from HSCs.

The study of the mechanisms of action of the microenvironment on megakaryopoiesis will allow us to propose new methods of production of platelets in vitro.

Work done with Catherine Strassel

Publications

Nothing found.