Team 2

Platelets, like all blood cells, are derived from hematopoietic stem cells. The team is interested in understanding the mechanisms that govern the different stages of this process, for which many questions remain. Increased knowledge of these mechanisms will lead to a better understanding of certain pathologies and to improve the in vitro production of platelets.

Several complementary aspects are addressed by the team:

• The role of the cellular microenvironment.
• The role of physical and mechanical forces and mechanotransduction.
• The interaction with the extracellular matrix through the role of the glycoprotein G6b-B.
• The transmigration through the wall of sinusoid vessels.
• The mechanisms of microtubule assembly.
• Thestudy of a signalling pathway mediated by the aromatic hydrocarbon receptor.
• In vitro platelet production from human progenitors for transfusion.